Irinotecan cas no. 97682-44-5 antineoplastic phamarceutical raw materials API

Irinotecan

Product name: Irinotecan

Synonyms:
1,4'-bipiperidine-1'-carboxylic acid(s)-4,11-diethyl-3,4,12,14-tetrahydro-4-
hydroxy-3,14-dioxo-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl ester

Molecular formula: C₃₃H₃₈N₄O₆

Molecular weight: 586.69

Appearance: Flaxen to yellow osteoporosis block or powder

CAS: 97682-44-5

Assay:99%

Indication: This product for the treatment of metastatic colorectal cancer, gastric cancer, esophageal cancer, extensive small cell lung cancer.

Pharmacology: Irinotecan is a semi-synthetic derivatives of camptothecin which can be specifically combined with the topoisomerase I. Topoisomerase I induced reversible single-strand breaks, so that double-stranded structure of DNA unwinded. Irinotecan and its active metabolite SN-38 with topoisomerase I-DNA complex binding, thereby preventing the fractured single-stranded nucleic acid to be connected. Existing research suggests that irinotecan cytotoxicity due to DNA synthesis process. Replicase and a topoisomerase I-DNA irinotecan (or SN-38) triple complex interactions, causing DNA double-strand breaks. Mammalian cells can not efficiently repair the DNA double-strand breaks   

SCIPHAR  The global health industry leader of raw materials
SCIPHAR  The specialist of global herbal extract industry
SCIPHAR  The specialist of natural products
SCIPHAR  The specialist of cosmetic ingredients 
SCIPHAR  Your professional and reliable partner